Ветеринарные антимикотики: эффективность нового препарата на основе хлоргексидина, климбазола, Трис-ЭДТА для снижения численности Malassezia pachydermatis на коже собак



Проведено пилотное исследование местного антимикотика для животных в форме влажных салфеток. Установлено, что антимикотик значительно снижал численность  pachydermatis на коже , что делает возможным его применение при малассезия-дерматитах губ, лап, перианальной области, кожных складок.

Wipes containing chlorhexidine and azole derivates have been recommended for veterinary use. No study has been published about their activity against Malassezia pachydermatis.
To evaluate the in vivo and in vitro activity of wipes soaked in a chlorhexidine, climbazole and Tris-EDTA solution against Malassezia pachydermatis.
Five research colony shar-pei dogs.

Wipes were applied once daily onto the left axilla, left groin and perianal area (protocol A), and twice daily on the right axilla, right groin and umbilical region (protocol B) for 3 days. In vivo activity was evaluated by quantifying Malassezia colonies through contact plates on the selected body areas before and after wipe application. The activity of the solution in which the wipes were soaked was assessed in vitro by contact tests following the European Standard UNI EN 1275 guidelines.

Efficacy of antifungal wipes against Malassezia on dog skin

Samples collected after wipe application showed a significant and rapid reduction of Malassezia yeast CFU. No significant difference in the Malassezia reduction was found between protocols A and B. In vitro assay showed 100% activity against Malassezia yeasts after a 15 min contact time with the wipe solution.

Wipes containing chlorhexidine, climbazole and Tris-EDTA substantially reduced the M. pachydermatis population on the skin of dogs. The results, although this was an uncontrolled study performed on a small number of dogs, suggest that these wipes may be useful for topical therapy of Malassezia dermatitis involving the lips, paws, perianal area and skin folds.

Authors: Paola Cavana et al. Read full text.

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